[FieldTrip] MNE Source Reconstruction Sanity Check

[Roey Schurr]

Dear fieldtrippers,



I want to do a sanity check on mne source reconstruction.

I'm working on continuous EEG recordings (19 electrodes), estimating the
source reconstruction activity using the *mne* (minimum norm estimate)
method, a *template MRI* (Colin27) and a *singlesphere* headmodel. As a
sanity check for the source reconstruction itself, I wanted to compare
conditions in which I could estimate the loci of significant changes, e.g.:
rest vs movement of the hand, moving the right hand vs the left hand, etc.
I have about 60 seconds of recording for each condition.



What I did was:

1) Segment the recording of each condition into many "trials" of 2 seconds
each.

2) For each trial, average the activity in each of the 90 ROIs of the aal
atlas (I excluded the cerebellum from the source reconstruction).



I was wondering what comparison would be best in this case. Since this is
not Evoked Responses data, I find it hard to find relevant ideas, and would
like to hear your thoughts.



1) I did a frequency analysis (mtmfft) in conventional bands of interest
and ran ft_freqstatistics on the resulting structures (using ttest2 and the
bonferoni correction for the multiple comparison problem). This gave some
results, however for most conditions they are not very encouraging (the
ROIs that showed significant differences were not close to those that I
have assumed).



*QUESTION 1*: do you think this is a proper method? Note that I did not use
a frequency based source reconstruction in the first place, because I'm
ultimately interested in the time course in the source space.



2) I was wondering if a cluster based permutation test is impossible to use
here, since this is a continuous recording, so clustering according to time
adjacency seems irrelevant.



*QUESTION 2*: is it possible to use a cluster based statistical test here?
If so, it could be better than a-priori averaging the source activity in
the atlas ROIs, which could mask some of the effects, if they are located
in a small area.



3) Another possibility is looking at the data itself. Unfortunately I
encountered some problems using ft_sourcemovie, though this is a subject
for a different thread.



Any thoughts and advice are highly appreciated!

Thank you for taking the time,

roey
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