<div dir="ltr"><p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">Dear fieldtrippers,</span></p>

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<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">I want to do a sanity
check on mne source reconstruction.</span></p>

<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">I'm working on
continuous EEG recordings (19 electrodes), estimating the source reconstruction
activity using the <b>mne</b> (minimum norm estimate) method, a <b>template
MRI</b> (Colin27) and a <b>singlesphere</b> headmodel. As a
sanity check for the source reconstruction itself, I wanted to compare
conditions in which I could estimate the loci of significant changes, e.g.:
rest vs movement of the hand, moving the right hand vs the left hand, etc. I
have about 60 seconds of recording for each condition.</span></p>

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<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">What I did was:</span></p>

<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">1) Segment the
recording of each condition into many "trials" of 2 seconds each.</span></p>

<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">2) For each trial,
average the activity in each of the 90 ROIs of the aal atlas (I excluded the
cerebellum from the source reconstruction).</span></p>

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<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">I was wondering what
comparison would be best in this case. Since this is not Evoked Responses data,
I find it hard to find relevant ideas, and would like to hear your thoughts.</span></p>

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<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">1) I did a frequency
analysis (mtmfft) in conventional bands of interest and ran ft_freqstatistics
on the resulting structures (using ttest2 and the bonferoni correction for the
multiple comparison problem). This gave some results, however for most
conditions they are not very encouraging (the ROIs that showed significant
differences were not close to those that I have assumed).</span></p>

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<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><b><span style="font-size:10pt;font-family:Arial,sans-serif">QUESTION 1</span></b><span style="font-size:10pt;font-family:Arial,sans-serif">: do you think this is a proper method? Note
that I did not use a frequency based source reconstruction in the first place,
because I'm ultimately interested in the time course in the source space.</span></p>

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<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">2) I was wondering if
a cluster based permutation test is impossible to use here, since this is a
continuous recording, so clustering according to time adjacency seems
irrelevant.</span></p>

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<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><b><span style="font-size:10pt;font-family:Arial,sans-serif">QUESTION 2</span></b><span style="font-size:10pt;font-family:Arial,sans-serif">: is it possible to use a cluster based
statistical test here? If so, it could be better than a-priori averaging the
source activity in the atlas ROIs, which could mask some of the effects, if
they are located in a small area.</span></p>

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<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">3) Another possibility
is looking at the data itself. Unfortunately I encountered some problems using
ft_sourcemovie, though this is a subject for a different thread.</span></p>

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<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">Any thoughts and
advice are highly appreciated!</span></p>

<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">Thank you for taking
the time,</span></p>

<p class="MsoNormal" style="margin-bottom:0.0001pt;background-image:initial;background-repeat:initial"><span style="font-size:10pt;font-family:Arial,sans-serif">roey</span></p></div>