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<h4 align="center" style="text-align:center"><strong><span lang="EN-US" style="font-size:11.0pt;font-family:"Arial",sans-serif;color:#10606F">5th International Congress on Mobile Health and Digital Technology in Epilepsy:</span></strong><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#10606F"><br>
<strong><span style="font-family:"Arial",sans-serif">Seizure Prediction Challenge Based on Ultra Long-Term EEG Recordings</span></strong></span><span lang="EN-US"><o:p></o:p></span></h4>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">Epilepsy affects millions of people worldwide, and one of its most debilitating aspects is the unpredictability of seizures. Advances in machine learning
and neurotechnology offer new opportunities to tackle this challenge. This competition invites researchers, data scientists, and clinicians to develop robust algorithms capable of predicting seizures using ultra long-term (months) EEG recordings with a subcutaneous
EEG device.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
<strong><span style="font-family:"Arial",sans-serif">Objective</span></strong></span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">Participants will create algorithms to predict seizure occurrences based on extended EEG covering several months of almost continuous subcutaneous
EEG recordings in a real life setting. The focus is on detecting pre-ictal states—specific patterns or biomarkers indicating an impending seizure—while minimizing false positives to ensure practical utility.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
<strong><span style="font-family:"Arial",sans-serif">Dataset</span></strong><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">The competition dataset comprises:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● A dataset containing ultra long-term EEG recordings from three patients using a 24/7 EEG SubQ device (UNEEG medical A/S, Lynge, Denmark) is provided
for the challenge. At least 25 lead seizures per patient are included in the training data.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Annotations marking seizures.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● An independent test dataset is used to evaluate submitted algorithms<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
<strong><span style="font-family:"Arial",sans-serif">Challenge Goals</span></strong><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Sensitivity: High detection rate of true pre-ictal periods.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Specificity: Minimizing false alarms to avoid undue burden on patients.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Scalability: Algorithms must handle ultra long-term recordings efficiently.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Generalizability: Solutions should perform well across diverse patients and seizure types.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
<strong><span style="font-family:"Arial",sans-serif">Evaluation Metrics</span></strong><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">Consider that your algorithm is developed to detect preictal periods that start 1h5min before seizures, and that a warning is useful if it is raised
at least five minutes before seizures. This means that a seizure occurrence period (SOP) of 1h and an intervention time (IT) of 5 min are considered.
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
<strong><span style="font-family:"Arial",sans-serif">Following metrics will be considered:</span></strong></span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Sensitivity(%): Defined as the ratio of predicted seizures.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Time in warning (TiW) (%): Defined as the fraction of time spent in alarm.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Improvement over chance (IoC) (%)<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Area Under the Receiver Operating Characteristic Curve (AUC-ROC).<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● False Alarm Rate (FAR) to assess the algorithm’s reliability.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">Latency: Time difference between predicted pre-ictal periods and actual seizure onset.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">Algorithms will be ranked using AUC-ROC<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
<strong><span style="font-family:"Arial",sans-serif">Competition Stages</span></strong></span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Development Phase: Access to training data and annotated seizures onset times for model development. Data will be supplied as EDF files.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Submission of algorithms and models to the organizers. Submission details will be given by May 1st.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
</span></b><strong><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">Publication policy</span></strong><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">The competition organizers aim at a joint publication with the winning teams. We explicitly discourage use of the data for publications independent
of this competition and this will not be covered by the download policies of the dataset.
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
<strong><span style="font-family:"Arial",sans-serif">Incentive</span></strong></span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Presentation of the algorithms of the teams at first and second position at the 5th International Congress on Mobile Health and Digital Technology
in Epilepsy<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Registration fee and hotel costs for the conference for one presenter of the two winning submissions.
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
<strong><span style="font-family:"Arial",sans-serif">Who Should Participate?</span></strong></span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">This challenge is open to:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Data scientists with expertise in time-series analysis and Artificial Intelligence/Machine Learning.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Neuroscientists and clinicians interested in translational research.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Multidisciplinary teams combining domain knowledge and technical expertise.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">Impact<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">The outcomes of this challenge have the potential to transform epilepsy management by enabling:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Early warnings for patients, improving their quality of life.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Development of closed-loop systems for seizure intervention.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Insights into the neurophysiology of seizure generation.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><o:p> </o:p></span></p>
<p class="MsoNormal"><strong><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">Timeline</span></strong><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Publication of the training dataset and reference algorithm: May 1st; 2025<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Submission deadline for algorithms: June 30th, 2025<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Running the algorithms on test dataset and ranking of contributions: July, 20th, 2025<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">● Presenting of winner algorithms in person or online: 4 - 6 September 2025, at International Congress on Mobile Health and Digital Technology in Epilepsy<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
<strong><span style="font-family:"Arial",sans-serif">Join the Challenge</span></strong><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">Be part of this groundbreaking effort to make seizures predictable and manageable. Collaborate, innovate, and push the boundaries of neurotechnology.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><br>
For more details on registration, dataset access, and timelines, visit </span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fna.eventscloud.com%2Femarketing%2Fgo.php%3Fid%3DcVThMLRcRs%252Fc9TmRD6toJPtCxfVaxV%252FO1FeudR8wInQaGT22YvELRDts%252BbZezb%252Bgh6bnsBpdAqgOo6ZexgWTOR%252Bkyl%252FNu%252BtMZfdRTjvFNMwkHdj1jsN%252B54ImA58jbWhqiubBo11TH4ZO%252BEwdDHaX5A%253D%253D&data=05%7C02%7Cfieldtrip%40science.ru.nl%7C73b5cbe488014020509a08dd9471e453%7C084578d9400d4a5aa7c7e76ca47af400%7C1%7C0%7C638829939081677226%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=1RaJAaEoPje0z5ufSfrUJc86dC%2F%2FW1Yoe6kPSLbQAUU%3D&reserved=0" originalSrc="https://na.eventscloud.com/emarketing/go.php?id=cVThMLRcRs%2Fc9TmRD6toJPtCxfVaxV%2FO1FeudR8wInQaGT22YvELRDts%2BbZezb%2Bgh6bnsBpdAqgOo6ZexgWTOR%2Bkyl%2FNu%2BtMZfdRTjvFNMwkHdj1jsN%2B54ImA58jbWhqiubBo11TH4ZO%2BEwdDHaX5A%3D%3D"><span lang="EN-US">https://epilongcontest.cisuc.uc.pt</span></a></span><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">
or contact </span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636"><a href="mailto:epilong@dei.uc.pt"><span lang="EN-US">epilong@dei.uc.pt</span></a></span><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#363636">.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Arial",sans-serif">On behalf the organizing team,</span><span lang="EN-US" style="font-family:"Arial",sans-serif;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Arial",sans-serif;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;mso-fareast-language:DE">PD Dr. Matthias Dümpelmann<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;mso-fareast-language:DE">UNIVERSITÄTSKLINIKUM FREIBURG<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;mso-fareast-language:DE">Abteilung Epileptologie<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;mso-fareast-language:DE">Neurozentrum<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;mso-fareast-language:DE">Breisacher Str. 64 · 79106 Freiburg<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;mso-fareast-language:DE">Telefon: +49 761 270-52410<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;mso-fareast-language:DE">matthias.duempelmann@uniklinik-freiburg.de</span><span style="mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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