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<p class="MsoNormal"><span lang="EN-US">Dear FieldTrip community,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">My name is Marlijn ter Bekke and I’m a PhD student at the Donders Institute and Max Planck Institute in Nijmegen. I work on multimodal language processing (speech + gesture) during conversation. Currently, I’m planning
the analysis for my first EEG study, and I have a question about the combined use of cluster-based permutation tests and linear mixed effects models.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">I’ve read about a strategy (e.g. <a href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00048/full">
here</a>) where people first use cluster-based permutation tests to e.g. find an effect of Condition, and then average over this cluster (in time/space/frequency) and use this average value as the dependent variable in linear mixed models. The benefit of this
approach is that parametric predictors that vary by subject (e.g. performance) or by item (e.g. word frequency) can easily be modeled.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">I wonder whether this strategy is good practice, given that the cluster-based permutation test cannot be used to conclude that the effect occurred in a particular time window, for particular electrodes or in particular
frequencies (see <a href="https://www.fieldtriptoolbox.org/faq/how_not_to_interpret_results_from_a_cluster-based_permutation_test/">
Fieldtrip FAQ</a> or <a href="https://doi.org/10.1111/psyp.13335">Sassenhagen & Draschkow, 2019</a>). Does it then make sense to use the found cluster as a basis for averaging? For example, if the test cannot say there was an effect specifically from e.g. 200-400ms,
then why average only over this time window?<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">I’d be very interested to hear your opinions on this matter!<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="NL">Best wishes,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL">Marlijn ter Bekke<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;color:#404040;background:white;mso-fareast-language:#2000"><a href="https://www.mpi.nl/people/bekke-marlijn-ter"><span lang="NL" style="color:#404040;text-decoration:none">Marlijn ter Bekke</span></a></span></b><b><span lang="NL" style="font-size:10.0pt;color:#404040;background:white;mso-fareast-language:#2000"><o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;color:#404040;background:white;mso-fareast-language:#2000">PhD student @ Donders Centre for Cognition<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:10.0pt;color:#404040;mso-fareast-language:#2000"><a href="https://www.ru.nl/english/people/bekke-m-ter/"><span lang="EN-US" style="color:#404040">https://www.ru.nl/english/people/bekke-m-ter/</span></a></span><span lang="EN-US" style="font-size:10.0pt;color:#404040;mso-fareast-language:#2000"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:10.0pt;color:#404040;mso-fareast-language:#2000"><a href="https://www.mpi.nl/people/bekke-marlijn-ter"><span lang="EN-US" style="color:#404040">https://www.mpi.nl/people/bekke-marlijn-ter</span></a></span><span lang="NL" style="font-size:10.0pt;color:#595959;mso-fareast-language:#2000">
</span><span lang="EN-US" style="font-size:10.0pt;color:#595959;mso-fareast-language:#2000"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
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