<div dir="ltr"><div>Hi Li Su,</div><div><br></div><div>What a coincidence, before posting my question I exactly read (amongst some others) your two papers you suggested. </div><div>Thanks for the suggestions :-)</div><div><br></div><div>Best,</div><div>Ingmar</div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">Op ma 29 mrt. 2021 om 17:16 schreef Li Su <<a href="mailto:ls514@cam.ac.uk">ls514@cam.ac.uk</a>>:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div style="overflow-wrap: break-word;">Hi Ingmar,<div><br></div><div>My suggestion is that if you are interested in the source, you’d better to do MNE localisation first and run RSA directly in the source space. Here are two papers from my own group applying this method.</div><div><span style="color:rgb(39,39,39);font-family:"Open Sans",sans-serif;font-size:16px"><br></span></div><div><b><span style="color:rgb(39,39,39);font-family:"Open Sans",sans-serif;font-size:16px">Wingfield, C., </span><span style="color:rgb(39,39,39);font-family:"Open Sans",sans-serif;font-size:16px;box-sizing:border-box">Su, L. </span><span style="color:rgb(39,39,39);font-family:"Open Sans",sans-serif;font-size:16px">, Liu, X., Zhang, C., Woodland, P., Thwaites, A., Fonteneau, E., Marslen-Wilson, W.D., (2017) Relating Dynamic Brain States to Dynamic Machine States: Human and Machine Solutions to the Speech Recognition Problem, PloS Computational Biology. <a href="http://doi.org/10.1371/journal.pcbi.1005617" target="_blank">doi.org/10.1371/journal.pcbi.1005617</a></span></b></div><div><b style="color:rgb(39,39,39);font-family:"Open Sans",sans-serif;font-size:16px;box-sizing:border-box"><br></b></div><div><b><span style="color:rgb(39,39,39);font-family:"Open Sans",sans-serif;font-size:16px;box-sizing:border-box">Su, L. </span><span style="color:rgb(39,39,39);font-family:"Open Sans",sans-serif;font-size:16px">, Fonteneau, E., Marslen-Wilson, W. and Kriegeskorte, N. (2012) Spatiotemporal Searchlight Representational Similarity Analysis in EMEG Source Space, IEEE Xplore, 97-100, doi:10.1109/PRNI.2012.26</span></b></div><div><br></div><div>Bw,</div><div><br></div><div>Li Su</div><div><br></div><div></div><div><br><div><div><span style="font-size:11px">— </span></div><div><div style="font-size:14px"><span style="font-size:11px"><b>Professor Li Su, PhD</b><br><font color="#011993">Chair of Neuroimaging</font></span></div><div style="font-size:14px"><font color="#011993"><span style="color:rgb(146,146,146);font-size:11px">Sheffield Institute for Translational Neuroscience, </span></font></div><div style="font-size:14px"><span style="font-size:11px"><font color="#011993"><span style="color:rgb(146,146,146)">University of Sheffield, </span></font><span style="color:rgb(146,146,146)">385A Glossop Road, </span></span></div><div style="font-size:14px"><span style="font-size:11px"><span style="color:rgb(146,146,146)">Sheffield, </span><span style="color:rgb(146,146,146)">S10 2HQ, UK</span></span></div><div style="font-size:14px"><font color="#011993" style="font-size:11px">Alzheimer’s Research UK Senior Research Fellow</font></div><div style="font-size:14px"><font color="#929292" style="font-size:11px">Department of Psychiatry, University of Cambridge, <br>Level E4, Box 189, Cambridge Biomedical Campus, <br>Cambridge, CB2 0SP, UK</font></div></div></div></div><div><br><blockquote type="cite"><div>On 29 Mar 2021, at 15:43, Ingmar de Vries <<a href="mailto:i.e.j.de.vries@gmail.com" target="_blank">i.e.j.de.vries@gmail.com</a>> wrote:</div><br><div><div dir="ltr"><div dir="ltr">Dear Fieldtrip community,<div><br></div><div>I have a conceptual question that potentially applies to many possible situations. If it helps, here is my situation: </div><div><br></div><div>I am currently analyzing MEG data (Neuromag, 306 sensors), using representational similarity analysis (RSA). I have applied a spatial searchlight at the sensor level, which results in RSA (i.e. correlation) values at each of the 306 sensors. This results in an interesting spatial peak of correlation above areas that are expected to be involved. </div><div><br></div><div>Is it possible to localize the cortical source of this sensor-level peak in correlation? </div><div>This question can be generalized to any metric, i.e.: Is it possible to localize the cortical source of any sensor-level metric?</div><div><br></div><div>I can't find any literature doing something similar, and the main problem I foresee is in the definition of a head model. That is, standard head models either define electrical conductivity (EEG), or spread of the magnetic field (MEG), but not the spread of an information-based metric (here correlation, but could be decoding accuracy as well). Is there a solution for this?</div><div><br></div><div>The alternative approach (plan B) would be to first apply source reconstruction on the raw MEG signal with a distributed source model (e.g. MNE), and subsequently apply the RSA analyses on the source-reconstructed signal. </div><div><br></div><div>Thanks for the input and I hope you are all healthy and safe, and able to continue your research in these strange times!</div><div><br></div><div>cheers,</div></div><div><br></div>-- <br><div dir="ltr"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div style="font-family:Tahoma,serif,EmojiFont;font-size:13px"><font style="font-family:Helvetica,serif,EmojiFont"><b>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~</b></font></div><div style="font-family:Tahoma,serif,EmojiFont;font-size:13px"><font style="font-family:Helvetica,serif,EmojiFont"><b>Ingmar de Vries, PhD.</b></font></div><div style="font-family:Tahoma,serif,EmojiFont;font-size:13px"><b><font style="font-family:Helvetica,serif,EmojiFont">Postdoc @ CIMeC, University of Trento</font></b><div><div><font style="font-family:Helvetica,serif,EmojiFont"><b><a href="mailto:i.e.j.de.vries@gmail.com" target="_blank">i.e.j.de.vries@gmail.com</a></b></font></div><div><span style="font-family:Helvetica,serif,EmojiFont"><b>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~</b></span></div></div></div></div></div></div></div></div></div></div>
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</blockquote></div><br clear="all"><div><br></div>-- <br><div dir="ltr" class="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div style="color:rgb(0,0,0);font-family:Tahoma,serif,EmojiFont;font-size:13px"><font style="font-family:Helvetica,serif,EmojiFont"><b>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~</b></font></div><div style="color:rgb(0,0,0);font-family:Tahoma,serif,EmojiFont;font-size:13px"><font style="font-family:Helvetica,serif,EmojiFont"><b>Ingmar de Vries, PhD.</b></font></div><div style="color:rgb(0,0,0);font-family:Tahoma,serif,EmojiFont;font-size:13px"><b><font style="font-family:Helvetica,serif,EmojiFont">Postdoc @ CIMeC, University of Trento</font></b><div><div><font style="font-family:Helvetica,serif,EmojiFont"><b><a href="mailto:i.e.j.de.vries@gmail.com" target="_blank">i.e.j.de.vries@gmail.com</a></b></font></div><div><span style="font-family:Helvetica,serif,EmojiFont"><b>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~</b></span></div></div></div></div></div></div></div></div></div></div>