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    <h1
style="margin:0cm;margin-bottom:.0001pt;mso-line-height-alt:12.0pt;background:white;vertical-align:baseline"><i><span
style="font-size:17.0pt;font-family:"Georgia","serif";mso-fareast-font-family:"Times
          New Roman";color:#2B2B2B;font-weight:normal">Post-doctoral
          position in the Theoretical Neuroscience Group - INS,
          Marseille, France<o:p></o:p></span></i></h1>
    <p
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          0cm;padding:0cm">Summary</span></b><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">The
        Theoretical Neuroscience Group (Head: Viktor Jirsa) is seeking
        to fill a post-doctoral position in the context of the project
        EPINOV to work on statistical & dynamical modeling of
        seizure propagation using personalized brain modeling and
        neuroinformatics approaches on a cohort of hundreds of epilepsy
        patients. EPINOV is one of 10 large-scale projects selected in
        the 3rd round of French scientific excellence program «RHU»
        managed by the National Research Agency (ANR). The aim of the
        EPINOV project is to significantly improve presurgical
        interpretation, guide surgical strategies and translate
        computational tools into clinical routine of personalized
        medicine. We use individual MRI scans to reconstruct brain
        anatomy and connectivity, which are combined with a neural mass
        model and fit using the Bayesian modeling software Stan to
        individuals’ intracranial electrophysiology data (stereotactic
        EEG), validated by clinical data from other modalities, such as
        MEG, fMRI, and semiology.</span><span style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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style="font-size:8.0pt;font-family:"Calibri","sans-serif""> </span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><b><span
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          0cm;padding:0cm">Responsibilities</span></b><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">•
        Scale up statistical models “vertically” to handle more data and
        higher resolution anatomy, using model comparison techniques to
        evaluate the advantage of different model structures</span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">•
        Scale out models “horizontally”, performing coherent, reliable
        inference across a large cohort of patients using dedicated,
        on-site HPC resources</span><span style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
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        Develop routines to evaluate and visualize inference results,
        making them amenable to clinical interpretation</span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">•
        Integrate developed code into existing code bases and pipelines</span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
style="margin:0cm;margin-bottom:.0001pt;line-height:12.0pt;vertical-align:baseline;outline:
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:8.0pt;font-family:"Calibri","sans-serif""> </span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
style="margin:0cm;margin-bottom:.0001pt;line-height:12.0pt;vertical-align:baseline;outline:
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><b><span
style="font-size:9.5pt;font-family:"Calibri","sans-serif";border:none
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          0cm;padding:0cm">Qualification </span></b><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">•
        Highly motivated to work on an interdisciplinary project and
        collaborate with the various members of the consortium. </span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">•
        PhD degree in computational neuroscience, mathematical or
        statistical modeling, machine learning or equivalent level of
        knowledge. </span><span style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
style="margin:0cm;margin-bottom:.0001pt;mso-line-height-alt:12.0pt;vertical-align:baseline;outline:
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">•
        Significant, demonstrable experience in data fitting (Bayesian
        modeling, Dynamical Causal Modeling (DCM), Monte Carlo, etc)
        will be highly appreciated. </span><span style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
style="margin:0cm;margin-bottom:.0001pt;mso-line-height-alt:12.0pt;vertical-align:baseline;outline:
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">•
        Experience with working in a Linux/HPC environment</span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
style="margin:0cm;margin-bottom:.0001pt;mso-line-height-alt:12.0pt;vertical-align:baseline;outline:
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">•
        Programming in a numerically oriented language (R, Python,
        MATLAB) </span><span style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
style="margin:0cm;margin-bottom:.0001pt;mso-line-height-alt:12.0pt;vertical-align:baseline;outline:
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">•
        Familiarity with Git, unit testing, Docker/VMs is a plus</span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
style="margin:0cm;margin-bottom:.0001pt;line-height:12.0pt;vertical-align:baseline;outline:
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:8.0pt;font-family:"Calibri","sans-serif""> </span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
style="margin:0cm;margin-bottom:.0001pt;line-height:12.0pt;vertical-align:baseline;outline:
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><b><span
style="font-size:9.5pt;font-family:"Calibri","sans-serif";border:none
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          0cm;padding:0cm">The Theoretical Neuroscience group </span></b><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
style="margin:0cm;margin-bottom:.0001pt;mso-line-height-alt:12.0pt;vertical-align:baseline;outline:
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">We
        are a multi-national team interested in understanding the
        mechanisms underlying the spatiotemporal organization of
        large-scale brain networks. Our work comprises mathematical and
        computational modeling of large-scale network dynamics and human
        brain imaging data, the development of neuroinformatics tools
        for studying large-scale brain networks applied to concrete
        functions, dysfunctions (epilepsy, dementia) and aging.</span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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style="font-size:8.0pt;font-family:"Calibri","sans-serif""> </span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><b><span
style="font-size:9.5pt;font-family:"Calibri","sans-serif";border:none
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          0cm;padding:0cm">Terms of salary and employment </span></b><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">A
        12-month renewable contract will be established. Salary will
        depend on the diploma and experience. Operating language in the
        laboratory is English. Applications including a cover letter,
        curriculum vitae and the names of two referees should be sent by
        September 30th 2017 to: Dr. Irene Yujnovsky at <a
          href="mailto:irene.yujnovsky@univ-amu.fr" target="_blank"><span
style="font-size:9.5pt;text-decoration:none;text-underline:none">irene.yujnovsky@univ-amu.fr</span></a> </span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
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style="font-size:8.0pt;font-family:"Calibri","sans-serif""> </span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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style="font-size:13.5pt;font-family:"Calibri","sans-serif";border:none
        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm">More
        information about the INS and the Theoretical Neurosciences
        Group can be found at: <a href="http://ins.univ-amu.fr/"
          target="_blank"><span
            style="font-size:9.5pt;text-decoration:none;text-underline:none">http://ins.univ-amu.fr</span></a></span><span
        style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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        windowtext 1.0pt;mso-border-alt:none windowtext 0cm;padding:0cm"><a
          href="http://ins.univ-amu.fr/" target="_blank"><span
            style="font-size:9.5pt;text-decoration:none;text-underline:none"><br>
          </span></a></span><span style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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          href="http://ins.univ-amu.fr/" target="_blank"><span
            style="font-size:9.5pt;text-decoration:none;text-underline:none"><br>
          </span></a></span><span style="font-size:8.0pt"><o:p></o:p></span></p>
    <p
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initial;background-attachment:scroll;background-position-x:0%;background-position-y:0%;word-spacing:0px"><span
        style="font-size:8.0pt"><a href="http://ins.univ-amu.fr/"
          target="_blank"><span style="font-size:9.5pt;border:none
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          </span></a></span><b><span
style="font-size:13.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-family:Arial">Clinical
          data manager for national consortium on epilepsy surgery - </span></b><b><span
style="font-size:13.0pt;font-family:"Verdana","sans-serif"">Aix-Marseille
          Université </span></b><span style="font-size:8.0pt"><o:p></o:p></span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;tab-stops:0cm"><b><span
style="font-size:13.0pt;font-family:"Verdana","sans-serif"">Marseille,
          FRANCE</span></b><o:p></o:p></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;tab-stops:0cm"><b><span
style="font-size:13.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-family:Arial"> </span></b><o:p></o:p></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span
          style="font-family:"Verdana","sans-serif""> </span></b><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-weight:bold">A
        position for an experienced clinical data manager is open to
        create and maintain an epileptic patient database including
        registration, normalization and security issues and to ensure
        the communication with the key partners in the academic,
        clinical and industry sectors with the aim </span><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif"">of
        generating individual Virtual Patient models using The Virtual
        Brain (TVB) platform as framework (see <a
          href="http://www.thevirtualbrain.org">http://www.thevirtualbrain.org</a>).<i
          style="mso-bidi-font-style:normal"> </i>This database will be
        generated in the context of the EPINOV (<i
          style="mso-bidi-font-style:normal">Improving EPilepsy surgery
          management and progNOsis using Virtual brain technology) </i>project<span
          style="mso-bidi-font-weight:bold"> led by Professor Fabrice
          Bartolomei (</span></span><a
href="http://fr.ap-hm.fr/service/neurophysiologie-clinique-hopital-timone"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif"">http://fr.ap-hm.fr/service/neurophysiologie-clinique-hopital-timone</span></a><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-weight:bold">)
        funded by the RHU programme.</span><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-weight:bold"> </span><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><b><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif"">Qualification</span></b><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><b><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif""> </span></b><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-weight:bold">Candidates
        must be highly motivated to work on an interdisciplinary project
        and collaborate with the various members of the consortium. They
        should have a degree in biomedical engineering, medical
        informatics or equivalent level of knowledge. Candidates must
        possess a solid experience in management of clinical and/or
        research data and programming (C, MATLAB, Python). Experience
        with neuroimaging data (stereotactic EEG, MRI, DTI, MEG, EEG),
        clinical trials, neuroinformatics and its standard formats (for
        instance DICOM, XNAT, BIDS), machine learning and Big Data would
        be considered an advantage. </span><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-weight:bold"> </span><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><b
        style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-family:Arial">The
          EPINOV project and consortium </span></b><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-family:Arial">We
        are a national consortium </span><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif"">composed
        of clinicians, researchers and industrial partners interested in
        improving epilepsy surgical prognosis using large–scale brain
        modelling based on individual epileptic patient data. A
        prospective, randomized multicenter trial will be conducted with
        subjects suffering from drug-resistant epilepsy. The clinical
        trial will systematically evaluate the added value of
        personalized brain modelling in the surgical decision making. </span><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif""> </span><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><b
        style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-family:Arial">Terms
          of salary and employment</span></b><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-family:Arial">Salary
        will depend on the diploma and previous experience. </span><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-weight:bold">Operating
        languages in the consortium are both French and English. </span><o:p></o:p></p>
    <p class="MsoNormal"
style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify"><span
style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-bidi-font-weight:bold"> </span><o:p></o:p></p>
    <pre style="text-align:justify"><span style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-ansi-language:EN-GB;mso-bidi-font-weight:bold" lang="EN-GB">Applications including a cover letter, curriculum vitae and the names of two referees should be sent by October 31st 2017 to: <b>Dr. Irene Yujnovsky</b> at </span><span style="font-size:11.0pt;font-family:"Verdana","sans-serif";mso-ansi-language:EN-GB" lang="EN-GB"><a href="mailto:irene.yujnovsky@univ-amu.fr">irene.yujnovsky@univ-amu.fr</a></span><o:p></o:p></pre>
    <p class="MsoNormal"><span
        style="mso-fareast-font-family:"Times New Roman""><o:p> </o:p></span></p>
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