<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 3.2//EN">
<HTML>
<HEAD>
<META HTTP-EQUIV="Content-Type" CONTENT="text/html; charset=us-ascii">
<META NAME="Generator" CONTENT="MS Exchange Server version 6.5.7654.12">
<TITLE>One or two sided testing?</TITLE>
</HEAD>
<BODY>
<!-- Converted from text/rtf format -->
<P DIR=LTR><SPAN LANG="nl"></SPAN><SPAN LANG="en-us"><FONT FACE="Calibri">Dear dr.</FONT></SPAN><SPAN LANG="nl"> <FONT FACE="Calibri">Maris</FONT></SPAN><SPAN LANG="nl"><FONT FACE="Calibri">,</FONT></SPAN><SPAN LANG="nl"></SPAN></P>
<P DIR=LTR><SPAN LANG="nl"></SPAN></P>
<P DIR=LTR ALIGN=CENTER><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"><FONT SIZE=1 FACE="Arial">Bovenkant formulier</FONT></SPAN></P>
<P DIR=LTR ALIGN=CENTER><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"><FONT SIZE=1 FACE="Arial">Onderkant formulier</FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"><FONT COLOR="#000000" FACE="Calibri">I notice that there are many</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"> <FONT COLOR="#000000" FACE="Calibri">different</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"> <FONT COLOR="#000000" FACE="Calibri">views among scientists</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"> <FONT COLOR="#000000" FACE="Calibri">about the use of</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"><FONT COLOR="#000000" FACE="Calibri"> one or two sided tests.<BR>
Most people say that you</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"> <FONT COLOR="#000000" FACE="Calibri">always</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"> <FONT COLOR="#000000" FACE="Calibri">have to test 2-sided.</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"> <FONT COLOR="#000000" FACE="Calibri">But is there a rationale for this?</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"> <FONT COLOR="#000000" FACE="Calibri">When is it appropriate and allowed to test one-sided?</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#000000" FACE="Calibri">Perhaps you can shed light on this topic</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"><FONT COLOR="#000000" FACE="Calibri">, by giving your point of view</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"> <FONT COLOR="#000000" FACE="Calibri">or perhaps you can recommend literature that provides insight on this</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"><FONT COLOR="#000000" FACE="Calibri"> debate</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en"><FONT COLOR="#000000" FACE="Calibri">?</FONT></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="nl"></SPAN><SPAN LANG="en-us"></SPAN></P>
<P DIR=LTR><SPAN LANG="nl"></SPAN><SPAN LANG="en-us"></SPAN></P>
<P DIR=LTR><SPAN LANG="nl"></SPAN><SPAN LANG="en-us"><FONT FACE="Calibri">Thank you,</FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"><FONT FACE="Calibri">Best Emanuel</FONT></SPAN><SPAN LANG="nl"></SPAN></P>
<P DIR=LTR><SPAN LANG="nl"></SPAN><SPAN LANG="en-us"></SPAN></P>
<P DIR=LTR><SPAN LANG="nl"></SPAN><SPAN LANG="nl-nl"></SPAN></P>
<P DIR=LTR><SPAN LANG="nl"></SPAN></P>
<br clear=all>
<html>
<body>
<p style="font-size:13px;font-family:arial;">
Het UMC St Radboud staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629.<BR> The Radboud University Nijmegen Medical Centre is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.<BR>
</p>
</body>
</html>
</BODY>
</HTML>